The Bacon Free Library, which opened in 1881, is located at 58 Eliot Street. This building was a gift to the community under the will of Oliver Bacon who died in 1878. It has been operating as a public library ever since. The library overlooks the Charles River in South Natick. The Natick Historical Society resides in the lower portion of the building.

Temple Israel of Natick, Natick's oldest Synagogue, is located on Hartford street. It is currently the largest Conservative Synagogue in the area, and serves many communities in the Metro West area.

The Natick Historical Society, located in the lower level of the Bacon Free Library. Archives and exhibits on John Eliot and Praying Indians, natural history collections, life during colonial times, early republic and industrial revolution, memorabilia of famous Natick citizens.

Eliot Church, originally founded as a meetinghouse in 1651, is the fifth structure on the site. The present church dates from the 1830s. A sign erected in front of the church in 1930, on the 300th anniversary of the founding of the Massachusetts Bay Colony, reads,"INDIAN MEETINGHOUSE – On this site John Eliot helped his Indian converts to build their first meetinghouse in 1651, with a 'prophet's chamber' where he lodged on his fortnightly visits to preach to them in their language. His disciple Daniel Takawambait succeeded to the pastoral office in 1698."

The U.S. Army Soldier Systems Center (SSC) (Also known as The Natick Army Labs), a complex of military R&D facilities, produces military-use items such as field rations, personal protective field equipment, and specialized uniforms. Natick Mall, managed by General Growth Properties, Inc. of Chicago, is one of Boston's premier shopping centers and recently[when?] completed a major expansion. The newly renovated wing opened 9/7/07.

Cognex Corporation Corporate Headquarters.

MathWorks Corporate Headquarters.

Boston Scientific Corporate Headquarters. This site used to be the HQ for mini-computer manufacturer Prime Computer, Inc. Before Prime, Carling ran a Black Label brewery there. The building was recently bought by MathWorks as an additional building to their currently expanding workforce.

The Walnut Hill School is one of the nation's leading private secondary schools, offering particular emphasis in the studio and performing arts. Walnut Hill graduates more students to the Juilliard School than any other secondary school in the world.

The Center for Arts in Natick (TCAN), located in Natick's historic Central Fire Station, is a favored performance venue for musicians in jazz, folk, classical, and rock genres. TCAN also hosts theatrical productions by the TCAN Players and children's classes in theatre and dance. Artists performing at TCAN have included Judy Collins, Don McLean, George Winston, Paula Poundstone, Shawn Colvin, Marshall Crenshaw, Jimmy Webb, Karla Bonoff, John Sebastian and Adrian Belew.

Casey's Diner, constructed in 1922, is one of the oldest operating ten-stool diners in the United States. Casey's Diner is diminutive in size at only 10 feet (3.0 m) by 20-1/2 feet, and was constructed by the Worcester Lunch Car Company in Worcester, Massachusetts. Famous for its steamed hot dogs, Casey's originated as a horse-drawn lunch wagon that was parked on Natick Common.

The Boden Lane Cemetery is a very small burial site established in 1815. Although the cemetery was established in that year, many of the gravestones are dated even earlier than this date, with some dating back to the Revolutionary War. The cemetery is located on Boden Lane, to the right of Beaver Dam, and directly across the street from the Chabad Center of Natick.

The Natick Community Organic Farm, located in South Natick on conservation land. It is a certified-organic, fully functioning working open year-round with no admission fee for the public's visits and purchases. The farm welcomes volunteers and runs a bevy of hands-on educational programs for adults and children. The farm has a barn built in 1815, a timber-framed nature center, two greenhouses, two hoophouses, four acres of market gardens, bee hives, woodland walking trails, a composting toilet, and a host of animals including chickens, turkeys, pigs, rabbits, sheep, goats, and cows.

Henry Wilson Shoe Shop, 181 West Central Street, listed on the National Register of Historic Places

Station Oak Tree, January 2012 The station tree is a 500-year-old black oak that the original surveyors used to mark the boundary between Natick and what was then part of Needham. That boundary is now the Natick-Weston town line on Winter Street, near the campus of The Rivers School in Weston, MA. One other notable landmark tree—the Eliot Oak next to the Eliot Church in South Natick—was removed in 1936 after the installation of underground gas lines damaged the root system, ultimately killing it.

The Chabad Center in Natick is a synagogue and Jewish educational center which is dedicated to strengthening Jewish awareness in the Metrowest area. The Hebrew School for the Arts is a breakthrough in typical Hebrew school education. Located at the Chabad Center, Hebrew School for the Arts teaches traditional Judaism while integrating the modern arts of drama.

Sassamon Trace Golf Course, built atop the former town landfill, is a branch of the Natick Recreation Department.

Natick's Recycle Center, adjacent to the town-owned golf course, and the High School athletic fields, serves the town's recycle needs.

St. Patrick's Church, located in Natick center, is Natick's Tallest structure, and is also the largest Roman Catholic Parish in Natick.

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